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The links below connect you to sites which offer information about what clinical trials are, how they are conducted, and listings of clinical trials open to brain
tumour patients. Since we do not maintain these sites, we are not responsible for the accuracy or content of the sites.
What Are Clinical Trials All About?
http://cancertrials.nci.nih.gov/
This National Cancer Institute site offers an explanation of clinical trials, how they are conducted, what to look for in a trial, and information about informed consent.
PDQ Clinical Trials Search
http://cnetdb.nci.nih.gov/trialsrch.shtml
PDQ is a database compiled by the National Cancer Institute. It contains several files, one of which is a list of clinical trials. That database includes over 100 brain
tumour trials which can be searched by tumour type, treatment type, sponsor type, patient age, or geographic region. Both US and international trials are listed.
List of Clinical Trials & Noteworthy Treatments
http://www.virtualtrials.com
Maintained by Al Musella, DPM, this site offers a database of both clinical trials and new, conventional treatments for brain
tumour patients. The database can be searched by treatment category, by state, or by
tumour type.
CenterWatch - Clinical Trials Listing Service
http://www.centerwatch.com
These trials are posted by physicians conducting research at major medical
centres and private research centres. Patients can use this site to learn about investigational therapies and identify ongoing clinical research trials. The information is provided by a publishing company covering clinical research as an information source to patients.
Pharmaceutical Research & Manufacturers Of America
http://www.phrma.org
PhRMA represents approximately 100 US companies involved in pharmaceutical research. Site includes industry information as well lists of members' new drugs in development.
Veritas Medicine
http://www.veritasmedicine.com
The Veritas Medicine website clinical trials database allows patients to be matched to clinical trials based on information submitted confidentially. The clinical trial matching tool is supplemented with original information about current and investigational treatments developed by physicians.
CLINICAL RESEARCH PROTOCOLS
FOR BRAIN CANCER IN ADOLESCENTS AND ADULTS
This list of clinical research protocols relating to brain cancer is
compiled for your convenience.
The following list of clinical trials for brain tumours in adults is
restricted to phase III studies. For more information about these trials,
as well as phase I and II trials in this area, contact PDQ directly.
MDA-DM-92035, NCI-T92-0114C Phase III Randomised Trial of PCV (PCB/CCNU/VCR)
With vs Without DFMO in Patients With Malignant Gliomas Who Have Received
Radiotherapy (summary last modified: 09/96).
Chairperson: Victor Alan Levin. Lead organization: University of Texas M.D.
Anderson Cancer Centre. Age range: 16 and over.
E-2394, SWOG-9508 Phase III Randomised Study of 3 Cycles of 3-Day
Continuous-Infusion BCNU/CDDP Followed by Radiotherapy vs Concurrent BCNU
and Radiotherapy for Newly Diagnosed Supratentorial Glioblastoma
Multiforme (summary last modified: 02/96).
Chairperson: Stuart A. Grossman. Lead organization: Eastern Cooperative
Oncology Group. Age range: 18 and over.
EORTC-26881 Phase III Comparison of BCNU vs BCNU/VCR/ Nimodipine in
Patients With Recurrent Malignant Gliomas (summary last modified:
08/92).
Chairperson: Marcel Chatel. Lead organization: EORTC Brain Tumour
Cooperative Group. Age range: 16 to 74.
EORTC-26882 Phase III Randomised Study of Radiotherapy With DBD
Radiosensitization Followed by DBD/BCNU vs Radiotherapy Alone for
Anaplastic Astrocytomas (summary last modified: 03/95).
Chairperson: J. Hildebrand. Lead organization: EORTC Brain Tumour
Cooperative Group. Age range: over 16.
EORTC-26951 Phase III Randomised Study of Radiotherapy with vs without
Adjuvant Procarbazine/ Lomustine/Vincristine (PCV) in Resected, Highly
Anaplastic Oligodendroglioma (summary last modified: 11/96).
Chairperson: M. J. van Den Bent. Lead organization: EORTC Brain Tumour
Cooperative Group. Age range: 16 to 69.
BB-C03/IVB/131, NCI-V96-0909 Phase III Randomised, Double- Blind,
Placebo-Controlled Study of Marimastat (a Matrix Metalloproteinase
Inhibitor) in Glioblastoma Multiforme or Gliosarcoma Following Completion
of Conventional First-Line Treatment (summary last modified: 01/97).
Chairperson: Terry Rugg. Lead organization: British Biotech, Inc. Age
range: 18 and over.
GTI-0115, NCI-V96-0990 Phase III Prospective, Open-Label, Parallel-
Group, Randomised, MulticentRe Trial Comparing the Efficacy of Surgery,
Radiation, and Injection of Murine Cells Producing Herpes Simplex
Thymidine Kinase Vector Followed by Intravenous Ganciclovir Against the
Efficacy of Surgery and Radiation in the Treatment of Newly Diagnosed,
Previously Untreated Glioblastoma Multiforme (summary last modified:
11/96).
Chairperson: Stephen G. Marcus. Lead organization: Novartis/ Genetic
Therapy Inc. Age range: 18 and over.
DTC-92-001, NCI-V97-1338 Phase III Study of Liposomal Cytarabine (DepoFoam
Encapsulated Cytarabine; DTC 101) vs Standard Therapy for Neoplastic
Meningitis in Patients With Leukaemia, Lymphoma, or Solid Tumours (summary
last modified: 12/97).
Chairperson: Linda Paradiso. Lead organization: DepoTech Corp. Age range:
3 and over.
NCCTG-937252, SWOG-9503 Phase III Randomised Study of BCNU Alone vs
BCNU/CDDP and of Standard vs Accelerated Radiotherapy for Grade IV Gliomas
(summary last modified: 10/97).
Chairperson: Jan C. Buckner. Lead organization: North Central Cancer
Treatment Group. Age range: 18 and over.
SWOG-9005, E-S9005 Phase III Randomised Double-Blind Trial of
Mifepristone vs Placebo for Unresectable Meningioma (summary last
modified: 04/97).
Chairperson: Steven M. Grunberg. Lead organization: Southwest Oncology
Group. Age range: 18 and over.
EORTC-22845, MRC-BR04 Phase III Randomised Comparison of Early vs No or
Late Radiotherapy in Adult Patients With Grade I/II Supratentorial
Astrocytomas and Oligodendrogliomas (summary last modified: 10/94).
Chairperson: A.B.M.F. Karim. Lead organization: EORTC Radiotherapy
Cooperative Group. Age range: 16 to 65.
RTOG-9305 Phase III Randomised Study of Radiosurgery Followed by
Conventional Radiotherapy With BCNU vs Conventional Radiotherapy With BCNU
in Patients With Supratentorial Glioblastoma Multiforme (summary last
modified: 05/96).
Chairperson: Luis Souhami. Lead organization: Radiation Therapy Oncology
Group. Age range: 18 and over.
RTOG-9402, INT-0149, NCCTG- 927252 Phase III Randomised Intergroup
Study of Intensive PCV (PCB/CCNU/VCR) Followed by Radiotherapy vs
Radiotherapy Alone for Pure and Mixed Anaplastic Oligodendrogliomas
(summary last modified: 08/94).
Chairperson: J. Gregory Cairn cross. Lead organization: Radiation Therapy
Oncology Group. Age range: 18 and over.
more
links
http://www.abta.org/
American Brain Tumour Association
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